TIBCO General Interface
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First released in 2001, this mature Ajax framework enables you to create Ajax components and applications that have the look and feel of desktop GUIs. With more than 100 components out of the box and a visual toolset for WYSIWYG assembly of screens. Available through open source BSD license as of Oct-2006.
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Related Projects 
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- Aejaks
Aejaks is a windowing toolkit to develop Ajax-based applications in Tcl, it's combines the server-side Ajax windowing system Echo2 with the powerful simplicity of the Tcl langauge. Æjaks is inspired by the Tcl/Tk windowing system for desktop applications. - AJFORM
AJFORM is a JavaScript toolkit which simply submits data from any given form in an HTML page, then sends the data to any specified JavaScript function. AJFORM degrades gracefully in every aspect. In other words, if the browser doesn't support it, the data will be sent through the form as normal. - mxAjax
mxAjax is easy Ajax implementation framework for coldfusion developers. - SmartClient from Isomorphic Software
SmartClient is the cross-platform AJAX GUI system chosen by top commercial software vendors, on-demand service providers, and enterprise IT developers for thousands of deployments since 2000. SmartClient provides a complete application stack, from rich, skinnable, extensible GUI components to declarative databinding and SOA integration, paired with a mature, searchable documentation suite and integrated tooling.
SmartClient AJAX applications run on Internet Explorer, Mozilla, Netscape, Firefox, and Safari web browsers, on Windows, MacOS, Linux, and Solaris. A Java integration server is provided, and SmartClient can also be integrated directly with any XML or JSON-based service without need of a server.
Visit SmartClient.com for hundreds of live examples, browseable documentation and a downloadable SDK.
- SwfJax
SwfJax is a new approach to asynchronous JavaScript and XML applications. It uses a lightweight SWF (Adobe's Small Web Format) engine to get XML data from the server and xPath (XML Path Language) to address a part of data it has retrieved. Data can be returned to Javascript as an Array
SwfJax is absolutely FREE and comes bundled with the latest version of Adobe's "Flash / JavaScript Integration Kit" to deliver the best available integration experience. - XAP
XAP is an XML-based declarative framework for building, deploying and maintaining rich, interactive Ajax powered web applications. It aims to reduce the need for scripting and help solve the development and maintenance challenges associated with large scale JavaScript programming.
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